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Cellular models of PML-RARα function have been hampered by the toxicity of the fusion protein, as underscored by studies in which the PML-RARα fusion protein could not be expressed after retroviral infection in nonhematopoietic cell lines and was expressed in only a few hematopoietic cell lines. PML-RARα retroviruses were difficult to generate due to the growth-suppressive effects of the protein on fibroblasts, including retroviral packaging cell lines.324-326
Endpoint Central automatically puts in the default installer options that are required to install an application. For example, if you are installing IE7, just create a package by selecting the appropriate msi. In the "Arguments to MSI", specify the arguments of the msi. Leave this field blank, if your MSI does not require any arguments.
Endpoint Central automatically puts in the default installation options that are required to install an application. For example, if you are installing ExcelViewer, just create a package by selecting the appropriate exe file. In the "Arguments to EXE", specify the arguments of the exe. Leave this field blank, if the EXE does not require any arguments.
Controls residing in Ontario were recruited during 2011 using a modified random digit dialing procedure and frequency matched to the expected case distribution by sex and 5-year age groups (previously described ). Of the 1734 controls who agreed to participate and were mailed study packages, 1285 (74%) returned the questionnaire and blood/saliva request form. Subjects who chose to give a saliva sample were mailed an Oragene DNA Self Collection Kit (DNA Genotek, Kanata, ON) (with instructions, consent forms, and a pre-paid reply envelope). Subjects who chose to give a blood sample were mailed a blood kit which they took to a laboratory under contract with the study for their blood draw. While 1285 controls completed questionnaires, only 608 (47%) provided a blood sample at a laboratory or mailed back a saliva sample (for DNA extraction). 041b061a72